Australian Society of CytologyCase of the Month
July 2002
Presented by:
Mark Stevens CFIAC
Principal Medical Scientist
Institute of Medical and Veterinary Science
Adelaide, Australia 5000
Specimen type:
Cervical smear
Clinical History:
42 year old female, previous laser treatment for CIN. Subsequent smears reported as normal.Images:
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| The current smear contained numerous clusters of cells showing branching, papillary and tubular-like arrrangements. |
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| The sheets showed crowded cells. Slit like spaces could be identified and these spaces were lined by columnar like cells. Some of the groups showed gland-like openings and again these were lined with columnar epithelium. |
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| Elsewhere, cells resembling endocervical cells were seen and these contained hyperchromatic nuclei, some of which were degenerate. |
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| In some clusters, nuclei were stripped of cytoplasm giving a "feathered" appearance to the group. At the edge of some clusters a suggestion of nuclear pseudostratification was apparent. Cells were also seen arranged in a rosette-like configuration and strips of cells could be seen coming off larger groups. |
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| On higher magnification, the cells showed moderate nuclear pleomorphism and prominent nucleoli. Cytoplasm was scant and poorly defined. |
Instructions:
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Answer
